Bristol Rovers v Southend
Bristol Rovers could have just 11 fit professionals available after five players fell ill with the virus which has also affected manager Ian Atkins.
Paul Trollope (head) is a doubt while Sonny Parker, Dave Savage, Ali Gibb are also ruled out with injury.
Southend's Jim Corbett has returned to light training after his ankle injury but is unlikely to make his return.
Bart Griemink (knee ligaments), Jay Smith (Achilles) and Andy Edwards (hamstring) are all missing.
Gas facing injury crisis
Bristol Rovers have a struggle on their hands to try and raise a team for Tuesday's LDV Vans Trophy Southern Area final at home to Southend.
Steve Elliott, John Anderson and Christian Edwards, who also has an ankle injury, Stuart Campbell and Ryan Williams have all been struck down by the virus which forced Ian Atkins to miss the defeat at Yeovil.
Craig Hinton could be left as the only recognised central defender, which would force Aaron Lescott to stand in at right-back, assuming he recovers from an ankle injury.
Paul Trollope, who partnered Hinton as a makeshift centre-half at Yeovil, took a blow to the head in that game and is another doubt.
Sonny Parker (knee), Dave Savage (hamstring) and Ali Gibb (cruciate ligament) will miss the first leg of the area final.
But Ryan Clarke will continue in goal as Kevin Miller is still not fit, leaving Atkins with only 11 fit professionals.
Wycombe v Scunthorpe
Wycombe will again be missing injured midfielder Joe Burnell, who suffered a knock in last weekend.
Rob Lee is training at the club but, without a deal, cannot play. However, latest signings Steve Claridge and David Perpetuini are in the squad.
Scunthorpe's new signing from Leeds, Andy Keogh, goes straight into the squad but Brian Laws is without banned Ian Baraclough.
Andy Butler is doubtful but veteran Peter Beagrie could return
Notts County v Northampton
Notts County player-manager Ian Richardson is expected to miss the clash with Northampton at Meadow Lane.
Defender Julien Baudet (ankle) is also out while Emmet Friars is doubtful because of a knee ligament injury.
Northampton have a doubt over central defender Ashley Westwood and Trevor Benjamin is suspended, but Lee Williamson returns from a ban.
Josh Low is still out with a groin injury as are David Galbraith (calf) and Marc Richards (knee).
Crewe v Burnley
Burnley defender Gary Cahill could miss the trip to Crewe after picking up a minor knock in the 2-0 win at Coventry.
If Cahill plays, boss Steve Cotterill may change his formation with Frank Sinclair returning from a one-match ban after his red card at Leeds.
Crewe may be rest defender Colin Mursock, who has played three games in seven days after two months without first-team football.
Luke Varney (dead leg) and Richard Walker (calf) could return
Colchester v Bournemouth
Colchester are without striker Craig Fagan, who completes a two-match ban.
Aidan Davison and Sam Stockley miss out through injury while Karl Duguid, Kem Izzet, Ben Bowditch, Richard Garcia and Jamie Cade are all out for the season.
Bournemouth defender Karl Broadhurst could feature in the squad after missing Saturday's 4-0 win over Oldham due to an ongoing hernia problem.
But they may be otherwise unchanged, with only Neil Young and Jason Tindall still missing through injury
Hartlepool v Luton
Hartlepool are sweating on Mark Tinkler (head) as they prepare to host table-topping Luton at Victoria Park.
Micky Barron comes in for the suspended Jack Ross at right-back, Jon Daly could make his debut, but Darrell Clarke is ruled out with a long-term knee injury.
Luton striker Steve Howard completes a two-match ban, so Enoch Showunmi should deputise again, although Calvin Andrew is pushing for a starting place.
Defender Paul Underwood is still sidelined with a hamstring problem.
Oldham v Wrexham
Oldham captain Dean Holden could return after suffering no reaction to his ankle injury when he came off the bench in Saturday's 4-0 loss at Bournemouth.
Will Haining (hamstring) could return, as should veteran David Eyres who was rested for the trip to Dean Court.
Wrexham are definitely without keeper Andy Dibble and defender Brian Carey.
Also, Chris Armstrong (thigh), Juan Ugarte (groin), Andy Holt (hamstring), Danny Williams (hamstring) and Steve Roberts (heel) are all doubtful.
Torquay v Peterborough
Torquay welcome back winger Tony Bedeau from suspension against Peterborough.
United are waiting on central defender Steve Woods (knee) before naming their starting line-up but Craig Woodman and Lee Canoville should be fit to start.
Peterborough have a doubt over Peter Kennedy, although X-rays have revealed that the arm he injured in training is bruised rather than broken.
Sagi Burton (hamstring and shoulder) is doubtful and Chris Plummer (ankle) is set to be out for at least a week.